If the evidence-based movement is to achieve success, it must demonstrate that model programs with strong evidence of producing impacts can be scaled-up to many new sites and continue having significant impacts on the social problems they are designed to solve. The July 2016 release of evaluations of 41 Teen Pregnancy Prevention (TPP) programs by the Office of Adolescent Health (OAH) was a major event in the attempt by the federal government to achieve scale-up. Examining the release carefully leads to a number of useful conclusions that hold promise for improving the federal scale-up process. Our review of results across the different types of projects begins with a general measure of the number and share of projects that produced at least one statistically significant impact on any of the seven measures of sexual behavior. This review is followed by a summary of impacts by projects on each of the seven individual measures of sexual behavior. In pondering these impacts, we raise six issues that are important not just for reflecting on this remarkable set of evaluations but also for a better understanding of the tiered-evidence strategy. We examine these issues and make recommendations because the tiered-evidence strategy has the potential to make the nation’s social policy more successful. The entire process of TPP grantmaking, project implementation, project evaluation, and project communication with researchers, policymakers, and the public provides a model for the future of federal grantmaking on social programs. However, if evidence-based policy is to fulfill its promise, the field cannot be satisfied with the level of impacts achieved by the TPP network. The vision of the field must be that programs supported by rigorous evidence will be developed to address and reduce the nation’s major social problems and to reliably produce impacts when implemented with fidelity in new settings.